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KMID : 0370220160600060312
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Yakhak Hoeji
2016 Volume.60 No. 6 p.312 ~ p.319
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Effects of Anomalin, Hyuganin C and Pteryxin on Phorbol Ester- or Tumor Necrosis Factor-induced Gene Expression, Production and Secretion of MUC5AC Mucin from airway Epithelial Cells
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Lee Hyun-Jae
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Abstract
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We investigated whether anomalin, hyuganin C or pteryxin affects airway MUC5AC mucin gene expression, production and secretion induced by phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-α (TNF-α) from NCIH292 cells. Cells were pretreated with each agent for 30 min and then stimulated with PMA or TNF-α for 24h. The three compounds inhibited the gene expression, production and secretion of MUC5AC mucin from NCI-H292 cells. This result suggests that anomalin, hyuganin C and pteryxin can inhibit the secretion, production and gene expression of mucin induced by PMA or TNF-α, through directly acting on airway epithelial cells.
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KEYWORD
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airway, mucin, anomalin, hyuganin C, pteryxin
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